2024

RESEARCH PAPERS

Bucknor MC, Gururajan A, Dale RC, Hofer MJ (2024). High fat diet consumption and social instability stress impair stress adaptation and maternal care in C57Bl/6 dams. Psychoneuroendocrinology. 169: 107168. doi: 10.1016/j.psyneuen.2024.107168

Verdillo R, Spiteri A, Viengkhou B, Wishart C, King NJC, Hofer MJ (2024). Interleukin-6 and interferon-alpha differentially regulate microglia function. Neuropathology and Applied Neurobiology 50(4): e13003. doi: 10.1111/nan.13003.

Viengkhou B, Hayashida E, McGlasson S, Emelianova K, Forbes D, Wiseman S, Wardlaw J, Verdillo R, Irani SR, Duffy D, Piehl F, Loo L, Pagenstecher A, Neely GG, Crow YJ, Campbell IL, Hunt DPJ, Hofer MJ (2024). The brain microvasculature is a primary mediator of interferon-a neurotoxicity in human cerebral interferonopathies. Immunity 57(7): 1696-1709. doi: 10.1016/j.immuni.2024.05.017

Spiteri AG, Suprunenko T, Cutts E, Suen A, Ashhurst TM, Viengkhou B, King NJC, Hofer MJ (2024). CD8+ T cells mediate lethal lung pathology in the absence of PD-L1 and type I interferon signalling following LCMV infection. Viruses. March 1; 16(3): 390. doi: https://www.mdpi.com/1999-4915/16/3/390

Viengkhou B, Hong, C, Mazur C, Damle S, Gallo NB, Fang TC, Henry K, Campbell IL, Kamme F, Hofer MJ (2024). Interferon-a receptor antisense oligonucleotides reduce neuroinflammation and neuropathology in a mouse model of cerebral interferonopathy. Journal of Clinical Investigation. Feb 14; 134(4):e169562. doi: https://doi.org/10.1172/JCI169562.

Reviews

Hofer MJ, Modesti N, Coufal NG, Wang Q, Sase S, Miner JJ, Vanderver A, Bennett ML (2024). The prototypical interferonopathy: Aicardi-Goutières syndrome from bedside to bench. Immunol Reviews. https://doi.org/10.1111/imr.13413

Hunt DPJ and Hofer MJ (2024). Unweaving type I interferons in age-related neuroinflammation. Trends in Neuroscience. 47(10):751-752. https://doi.org/10.1016/j.tins.2024.08.014

2023

Research papers

Harney DJ, Cielesh M, Roberts GE, Vial IK, Viengkhou B, Hofer MJ, Laguette N, Larance M (2023). Dietary restriction induces a sexually dimorphic type I interferon response in mice with gene-environment interactions. Cell Reports. May 26; 42(6):112559

Spiteri AG, Wishart C, Ni D, Viengkhou B, Macia L, Hofer MJ, King NJC (2023). Temporal tracking of microglial and monocyte single-cell transcriptomics in lethal flavivirus infection. Acta Neuropathologica Communications. Apr 4; 11(1):60.

REVIEWS

Vienkhou B and Hofer MJ (2023). Breaking down the cellular responses to type I interferon neurotoxicity in the brain. Frontiers in Immunology. Feb 03. doi: 10.3389/fimmu.2023.1110593

2022

Research papers

West PK, Viengkhou B, Campbell IL, Hofer MJ (2022). Microglia shield the murine brain from damage mediated by the cytokines IL-6 and IFN-alpha. Frontiers in Immunology. Oct. 13; 13:1036799.

Syme TE, Grill M, Hayashida E, Viengkhou B, Campbell IL, Hofer MJ (2022). Strawberry notch homolog 2 regulates the response to interleukin-6 in the central nervous system. J. Neuroinflammation. May 27; 19(1):126.

West PK, McCorkindale AN, Guennewig B, Ashhurst TM, Viengkhou B, Hayashida E, Jung SR, Butovsky O, Campbell IL, Hofer MJ (2022). The cytokines interleukin-6 and interferon-α induce distinct microglia phenotypes. J. Neuroinflammation. Apr 16; 19(1):96.

Spiteri AG, Ni D, Ling Z, Macia L, Campbell IL, Hofer MJ, King NJC (2022). PLX5622 reduces disease severity in lethal CNS infection by off-target inhibition of peripheral inflammatory monocyte production. Frontiers in Immunology. Mar 25; 13:851556.

REVIEWS

Bucknor MC, Gururajan A, Dale RC, Hofer MJ (2022). A comprehensive approach to modeling maternal immune activation in rodents. Frontiers in Neuroscience. Dec 16. doi.org/10.3389/fnins.2022.1071976

Telikani Z, Monson EA, Hofer MJ, Helbig KJ (2022). Antiviral response within different cell types of the CNS. Frontiers in Immunology. Nov 15; 13:1044721.

Han VX, Jones HF, Patel S, Mohammad SS, Hofer MJ, Gold W, Brilot F, Dale RC (2022). Emerging evidence of Toll-like receptors as a putative pathway linking maternal inflammation and neurodevelopmental disorders in human offspring: a systematic review. Brain Behavior and Immunity. Jan;99:91-105

2021

Research papers

Viengkhou B, White MY, Cordwell SJ, Campbell IL, Hofer MJ (2021). A novel phosphoproteomic landscape evoked in response to type I interferon in the brain and in glial cells. J. Neuroinflammation. Oct 16;18(1):237

Spiteri AG, Terry RL, Wishart CL, Ashhurst TM, Campbell IL, Hofer MJ, King NJC (2021). High-parameter cytometry unmasks microglial cell spatio-temporal response kinetics in severe neuroinflammatory disease. J. Neuroinflammation. Jul 26; 18(1):166

O'Rourke MB, Viengkhou B, Smith CC, Sonderegger L, Padula MP, Sutherland GT, Hofer MJ, Crossett B (2021). Matrix phase fractionation: Investigating the compromise between dynamic range of analyte extraction and spatial resolution in mass spectrometry imaging. Rapid Comm. in Mass Spectrometry. Jun 15; 35(13):e9106

Jones HF, Han VX, Patel S, Gloss BS, Soler N, Ho A, Sharma S, Kothur K, Nosadini M, Wienholt L, Hardwic C, Barne EH, Li JR, Alshammery S, Nielsen TC, Wong M, Hofer MJ, Nassar N, Gold W, Brolot F, Mohammad SS, Dale RC (2021). Maternal Autoimmunity and Inflammation are Associated with Childhood Tics and Obsessive-Compulsive Disorder: Transcriptomic Data show Common Enriched Innate Immune Pathways. Brain Behav Immun. May;94:308-317

ReVIEWS

Han VX, Patel S, Jones HF, Nielsen TC, Mohammad SS, Hofer MJ, Gold W, Brilot F, Lain SJ, Nassar N, Dale RC (2021). Maternal acute and chronic inflammation in pregnancy is associated with common neurodevelopmental disorders: a systematic review. Transl Psychiatry. Jan 21;11(1):71.

2020

Research papers

Jung SR, Ashhurst TM, West PK, Viengkhou B, King NJC, Campbell IL, Hofer MJ (2020). Contribution of STAT1 to innate and adaptive immunity during type I interferon-mediated lethal virus infection. PLoS Pathogens 16(4):e1008525.

2019

Research papers

Hayashida E, Ling Z, Ashhurst TM, Viengkhou B, Jung SR, Songkhunawej P, West PK, King NJC, Hofer MJ (2019). Zika virus encephalitis in immunocompetent mice is dominated by innate immune cells and does not require T or B cells. J. Neuroinflammation.

Nitsch L, Zimmermann J, Krauthausen M, Hofer MJ, Saggu R, Petzold GC, Heneka MT, Getts DR, Becker A, Campbell IL, Müller M (2019). CNS-specific synthesis of interleukin 23 induces a progressive cerebellar ataxia and the accumulation of both T and B cells in the brain: characterization of a novel transgenic mouse model. Mol. Neurobiol. [Epub ahead of print].

Jones HF, Ho ACC, Sharma S, Mohammad SS, Kothur K, Patel S, Brilot F, Guastella AJ, Dale RC; Immune-Neurodevelopment (Imm-Nd) Study Group [Nosadini M, Shah U, Down J, Gold W, Hofer MJ] (2019). Maternal thyroid autoimmunity associated with acute-onset neuropsychiatric disorders and global regression in offspring. Dev Med Child Neurol. Feb 5 [Epub ahead of print].

Reviews

West PK, Viengkhou B, Campbell IL, Hofer MJ (2019). Microglia responses to interleukin-6 and type I interferons in neuroinflammatory disease. Glia. Oct; 67(10):1821–41.

Suprunenko T and Hofer MJ (2019). Complexities of type I interferon biology: Lessons from LCMV. Viruses. Feb 20: 11(2).

Thompson CL and Hofer MJ (2019). Too much of a good thing. Australasian Science. 40(4):24–5.

2018

Research papers

Jung SR, Surpunenko T, Ashhurst T, King NJC, Hofer MJ (2018). Collateral damage: What effect does anti-CD4 and anti-CD8alpha antibody-mediated depletion have on leukocyte populations? J. Immunol. Oct 1; 201(7):2176–86.

Li W, Viengkhou B, Denyer G, West PK, Campbell IL, Hofer MJ (2018). Microglia have a more extensive and divergent response to interferon-a compared with astrocytes. Glia. Oct; 66(10):2058–78.

2017

Research papers

Huber M, Suprunenko T, Ashhurst T, Marbach F, Raifer H, Wolff S, Strecker T, Viengkhou B, Jung SR, Obermann HL, Bauer S, Xu HC, Lang P, Tom A, Lang KS, King NJC, Campbell IL, Hofer MJ (2017). IRF9 prevents CD8+ T cell exhaustion in an extrinsic manner during acute LCMV infection. J. Virology. Oct 27:91(22)e01219–17.

Li W, Hofer MJ, Songkhunawej P, Jung SR, Hancock D, Denyer G, Campbell IL (2017). Type I interferon-regulated gene expression and signaling in murine mixed glial cells lacking signal transducers and activators of transcription 1 or 2 or interferon regulatory factor 9. J Biol Chem. 292(14):5845–59.

Vachharajani N, Joeris T, Luu M, Hartmann S, Pautz S, Jenike E, Pantazis G, Prinz I, Hofer MJ, Steinhoff U, Visekruna A (2017). Prevention of colitis-associated cancer by selective targeting of immunoproteasome subunit LMP7. Oncotarget. 8(31):50447–59.

2016

Reviews

Suprunenko T, Hofer MJ (2016). The emerging role of interferon regulatory factor 9 in the antiviral host response and beyond Cytokine Growth Factor Rev. 29:35–43.

Hofer MJ, Cambell IL (2016). Immunoinflammatory diseases of the central nervous system – the tale of two cytokines. Br J Pharmacol. Feb;173(4):716–28.

2015

Research papers

Mikaelyan A, Thompson CL, Hofer MJ, Brune A (2015). The deterministic assembly of complex bacterial communities in germ-free cockroach guts. Appl Environ Microbiol. 82(4):1256–63.

Campbell LT, Simonin AR, Chen C, Ferdous J, Padula MP, Harry E, Hofer M, Campbell IL, Carter DA (2015). Cryptococcus strains with different pathogenic potentials have diverse protein secretomes. Eukaryot Cell. 14(6):554–63.

Almolda B, de Labra C, Barrera I, Gruart A, Delgado-Garcia JM, Villacampa N, Vilella A, Hofer MJ, Hidalgo J, Campbell IL, González B, Castellano B (2015). Alterations in microglial phenotype and hippocampal neuronal function in transgenic mice with astrocyte-targeted production of interleukin-10 Brain. Behavior and Immunity. 45:80–97.

Visekruna A, Linnerz T, Martinic V, Vachharajani N, Hartmann S, Harb H, Joeris T, Pfefferle PI, Hofer MJ, Steinhoff U (2015). Transcription factor c-Rel plays a crucial role in driving anti-CD4-mediated innate colitis. Mucosal Immunology. 8(2):307–15.

2014

Research papers

Li W, Hofer MJ, Jung SR, Lim SL, Campbell IL (2014). IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus. J. Virol. 88(13):7578–88.

Nocon AL, Ip JP, Terry R, Lim SL, Getts DR, Mueller M, Hofer MJ, King NJ, Campbell IL (2014). The bacteriostatic protein lipocalin 2 is induced in the central nervous system of mice with West Nile virus  encephalitis. J. Virol. 88(1):679–89.

Teymoortash A, Zieger L, Hoch S, Pagenstecher A, Hofer MJ (2014). Distinct microscopic features of perineural invasion in adenoid cystic carcinoma of the head and neck. Histopathology. 23(1):105–8.

2013

Research papers

Siegfried A, Berchtold S, Manncke B, Deuschle E, Reber J, Ott T, Weber M, Kalinke U, Hofer MJ, Hatesuer B, Schughart K, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Weber F, Hornef MW, Autenrieth IB, Bohn E (2013). IFIT2 is an effector protein of type I interferon-mediated amplification of lipopolysaccharide (LPS)-induced TNF-a secretion and LPS-induced endotoxin shock. J. Immunol. 191(7):3913–21.

Li W, Hofer MJ, Nocon AL, Manders P, Campbell IL (2013). Interferon Regulatory Factor 7 (IRF7) is required for the optimal initial control but not subsequent clearance of lymphocytic choriomeningitis virus infection in mice. Virology. 439(2):152–62.

Zimmermann J, Krauthausen M, Hofer MJ, Heneka MT, Campbell IL, Muller M (2013). CNS-targeted production of IL-17A induces glial activation, microvascular pathology and enhances the neuroinflammatory response to systemic endotoxemia. PLoS One. 8(2):e57307.

Reviews

Hofer MJ, Campbell IL (2013). Type I interferon in neurological disease – the devil from within. Cytokine Growth Factor Rev. 24(3):257–67.

case reports

Hofer MJ, Rohlfs J, Teymoortash A, Pagenstecher A (2013). A 62-yer-old female with an intranasal mass extending into the lamina cribrosa. Brain Pathol. 23(1):105–8.

Bujan B, Hofer MJ, Oertel WH, Pagenstecher A, Burk K (2013). Multiple system atrophy of the cerebellar type (MSA-C) with concomitant beta-amyloid and tau pathology. Clin Neuropathol. Jul–Aug;32(4):286–90.

2012

Research papers

Hofer MJ, Riehmer V, Kuhnt D, Braun V, Nimsky C, Weber RG, Sommer C, Pagenstecher A (2012). Genomic profiling to assess the clonal relationship between histologically distinct intracranial tumours. Neuropathol Appl Neurobiol. 38(5):500–4. 

Getts DR, Terry RL, Getts MT, Muller M, Rana S, Deffrasnes C, Ashurst TM, Radford J, Hofer M, Thomas S, Campbell IL, King NJ. Targeted blockade in lethal WNV encephalitis indicates a cruial role for very late antigen (VLA)-4-dependent recruitment of nitric oxide-producing macrophages (2012). J. Neuroinflammation. Oct 30;9:246.

Hofer MJ, Li W, Manders P, Terry R, Lim SL, King NJ, Campbell IL (2012). Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus. J Virol. 86(12):6932–46.

case reports

Ghadourah S, Hofer MJ, Kießling A, El-Zayat B, Shofer MD (2012). Painful muscle fibrosis following synthol injections in a bodybuilder: a case report. J Med Case Rep. 6(1):248.